The proposal that diabetes plays a role in the development of heart failure is supported by the increased risk associated with this disease, even after correcting for all other known risk factors. However, the precise mechanisms contributing to the condition referred to as diabetic cardiomyopathy have remained elusive, as does defining the disease itself. Decades of study have defined numerous potential factors that each contribute to disease susceptibility, progression, and severity. Many recent detailed reviews have been published on mechanisms involving insulin resistance, dysregulation of microRNAs, and increased reactive oxygen species, as well as causes including both modifiable and non-modifiable risk factors. As such, the focus of the current review is to highlight aspects of each of these topics and to provide specific examples of recent advances in each area.

Citations

Citations to this article as recorded by  

• Upregulation of PCSK9, rho kinase and cardiac troponin by Eucalyptus globulus leaf extract improves fructose-streptozotocin-induced diabetic cardiac dysfunction in rats
  Afolabi C. Akinmoladun, Morenikejimi Bello, Emmanuel Oluwafemi Ibukun
  Archives of Physiology and Biochemistry.2023; 129(6): 1219.     CrossRef
• An Overview of Cardiotonic Medicinal Plants from the Perspective of Iranian Traditional Medicine
  Akram Alembagheri, Homa Hajimehdipoor, Rasool Choopani, Somayeh Esmaeili
  Jundishapur Journal of Natural Pharmaceutical Products.2023;[Epub]     CrossRef
• Nanoformulations for the Delivery of Dietary Anthocyanins for the Prevention and Treatment of Diabetes Mellitus and Its Complications
  Ana R. Nunes, Elisabete C. Costa, Gilberto Alves, Luís R. Silva
  Pharmaceuticals.2023; 16(5): 736.     CrossRef
• Cyp2e1 knockdown attenuates high glucose-induced apoptosis and oxidative stress of cardiomyocytes by activating PI3K/Akt signaling
  Jianying Wang, Han Yang, Chao Wang, Cuie Kan
  Acta Diabetologica.2023; 60(9): 1219.     CrossRef
• Role of vascular endothelial growth factor B in nonalcoholic fatty liver disease and its potential value
  Yu-Qi Li, Lei Xin, Yu-Chi Zhao, Shang-Qi Li, Ya-Nuo Li
  World Journal of Hepatology.2023; 15(6): 786.     CrossRef
• Non-Invasive Assessment of the Intraventricular Pressure Using Novel Color M-Mode Echocardiography in Animal Studies: Current Status and Future Perspectives in Veterinary Medicine
  Ahmed S. Mandour, Ahmed Farag, Mahmoud A. Y. Helal, Gamal El-Masry, Salim Al-Rejaie, Ken Takahashi, Tomohiko Yoshida, Lina Hamabe, Ryou Tanaka
  Animals.2023; 13(15): 2452.     CrossRef
• Diet‐induced prediabetes: Effects on the activity of the renin–angiotensin–aldosterone system in selected organs
  Bongeka Cassandra Mkhize, Palesa Mosili, Phikelelani Sethu Ngubane, Ntethelelo Hopewell Sibiya, Andile Khathi
  Journal of Diabetes Investigation.2022; 13(5): 768.     CrossRef
• Knowledge domain and emerging trends in diabetic cardiomyopathy: A scientometric review based on CiteSpace analysis
  Shiyi Tao, Deshuang Yang, Lanxin Zhang, Lintong Yu, Zihan Wang, Lingling Li, Jin Zhang, Ruiqi Yao, Li Huang, Mingjing Shao
  Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
• Clinical Evidence and Proposed Mechanisms for Cardiovascular and Kidney Benefits from Sodium–Glucose Co-transporter-2 Inhibitors
  Joshua J Neumiller, Fredrick J Lienhard, Radica Z Alicic, Katherine R Tuttle
  European Endocrinology.2022; 18(2): 106.     CrossRef
• Protective effects of medicinal plant against diabetes induced cardiac disorder: A review
  Sadegh Shabab, Zahra Gholamnezhad, Maryam Mahmoudabady
  Journal of Ethnopharmacology.2021; 265: 113328.     CrossRef
• Toward a broader view of mechanisms of drug cardiotoxicity
  Polina Mamoshina, Blanca Rodriguez, Alfonso Bueno-Orovio
  Cell Reports Medicine.2021; 2(3): 100216.     CrossRef
• Cardioprotective Effect of Glycyrrhizin on Myocardial Remodeling in Diabetic Rats
  Vikram Thakur, Narah Alcoreza, Monica Delgado, Binata Joddar, Munmun Chattopadhyay
  Biomolecules.2021; 11(4): 569.     CrossRef
• Cardioprotective Action of Glycyrrhizin on Diabetic Rats with Myocardial Remodeling
  Fuxu Chen, Jie Song, Enas Abdulhay
  Journal of Healthcare Engineering.2021; 2021: 1.     CrossRef
• Management of inflammation in cardiovascular diseases
  Sumanta Kumar Goswami, Prabhat Ranjan, Roshan Kumar Dutta, Suresh Kumar Verma
  Pharmacological Research.2021; 173: 105912.     CrossRef
• Diabetic Cardiomyopathy: Clinical and Metabolic Approach
  Dragan B. Djordjevic, Goran Koracevic, Aleksandar D. Djordjevic, Dragan B. Lovic
  Current Vascular Pharmacology.2021; 19(5): 487.     CrossRef
• Effect of Acute Chemotherapy on Glucose Levels in Rats
  Ahmad H. Alhowail, Gena S. Alfawzan, Maha A. Aldubayan, Lolwah S. Alsalam
  International Journal of Pharmacology.2020; 16(3): 276.     CrossRef
• Transplantation of adipose tissue lacking PAI-1 improves glucose tolerance and attenuates cardiac metabolic abnormalities in high-fat diet-induced obesity
  Sijing Liu, Yi Li, Xin Fan, Kai Li, Chunrong Xu, Liping Zhang, Mao Luo, Liqun Wang, Rong Li, Jianbo Wu
  Adipocyte.2020; 9(1): 170.     CrossRef
• Cardiometabolic-Based Chronic Disease, Adiposity and Dysglycemia Drivers
  Jeffrey I. Mechanick, Michael E. Farkouh, Jonathan D. Newman, W. Timothy Garvey
  Journal of the American College of Cardiology.2020; 75(5): 525.     CrossRef
• Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review
  Fahmi Shaher, Hongbin Qiu, Shuqiu Wang, Yu Hu, Weiqun Wang, Yu Zhang, Yao Wei, Hisham AL-ward, Mahfoudh A. M. Abdulghani, Sattam Khulaif Alenezi, Salem Baldi, Shaobo Zhou
  BioMed Research International.2020; 2020: 1.     CrossRef
• Human trophoblast-derived exosomes attenuate doxorubicin-induced cardiac injury by regulating miR-200b and downstream Zeb1
  Jie Ni, Yihai Liu, Lina Kang, Lian Wang, Zhonglin Han, Kun Wang, Biao Xu, Rong Gu
  Journal of Nanobiotechnology.2020;[Epub]     CrossRef
• Clinical Evidence and Proposed Mechanisms for Cardiovascular and Kidney Benefits from Glucagon-like Peptide-1 Receptor Agonists
  Emily J Cox, Radica Z Alicic, Joshua J Neumiller, Katherine R Tuttle
  US Endocrinology.2020; 16(2): 80.     CrossRef
• Hyperbaric Oxygen Therapy Dampens Inflammatory Cytokine Production and Does Not Worsen the Cardiac Function and Oxidative State of Diabetic Rats
  Rita Benkő, Zsuzsanna Miklós, Viktor Antal Ágoston, Katrine Ihonvien, Csaba Répás, Roland Csépányi-Kömi, Margit Kerék, Nóra Judit Béres, Eszter Mária Horváth
  Antioxidants.2019; 8(12): 607.     CrossRef
• Heart Failure in Type 2 Diabetes Mellitus
  Helena C. Kenny, E. Dale Abel
  Circulation Research.2019; 124(1): 121.     CrossRef
• SGLT2 inhibition with empagliflozin improves coronary microvascular function and cardiac contractility in prediabetic ob/ob−/− mice
  Damilola D. Adingupu, Sven O. Göpel, Julia Grönros, Margareta Behrendt, Matus Sotak, Tasso Miliotis, Ulrika Dahlqvist, Li-Ming Gan, Ann-Cathrine Jönsson-Rylander
  Cardiovascular Diabetology.2019;[Epub]     CrossRef
• Depressive symptoms in asymptomatic stage B heart failure with Type II diabetic mellitus
  Paul J. Mills, Pam R. Taub, Ottar Lunde, Meredith A. Pung, Kathleen Wilson, Christopher Pruitt, Thomas Rutledge, Alan Maisel, Barry H. Greenberg
  Clinical Cardiology.2019; 42(6): 637.     CrossRef
• Pathophysiological mechanisms of diabetic cardiomyopathy and the therapeutic potential of epigallocatechin-3-gallate
  Amir M. Al Hroob, Mohammad H. Abukhalil, Omnia E. Hussein, Ayman M. Mahmoud
  Biomedicine & Pharmacotherapy.2019; 109: 2155.     CrossRef
• The Janus face of HMGB1 in heart disease: a necessary update
  Angela Raucci, Stefania Di Maggio, Francesco Scavello, Alessandro D’Ambrosio, Marco E. Bianchi, Maurizio C. Capogrossi
  Cellular and Molecular Life Sciences.2019; 76(2): 211.     CrossRef
• Histological evidence of chitosan-encapsulated curcumin suppresses heart and kidney damages on streptozotocin-induced type-1 diabetes in mice model
  Sabri Sudirman, Ching-Shu Lai, Yi-Ling Yan, Hung-I Yeh, Zwe-Ling Kong
  Scientific Reports.2019;[Epub]     CrossRef
• Microarray profiling analysis identifies the mechanism of miR‐200b‐3p/mRNA‐CD36 affecting diabetic cardiomyopathy via peroxisome proliferator activated receptor‐γ signaling pathway
  Liqiong Xu, Wei Chen, Min Ma, Anfang Chen, Chengyue Tang, Chengwei Zhang, Lin Cai
  Journal of Cellular Biochemistry.2019; 120(4): 5193.     CrossRef
• Plasma Low-Density Lipoprotein Cholesterol Correlates With Heart Function in Individuals With Type 2 Diabetes Mellitus: A Cross-Sectional Study
  Po-Chung Cheng, Shang-Ren Hsu, Jung-Chi Li, Ching-Pei Chen, Szu-Chi Chien, Shih-Te Tu, Yun-Chung Cheng, Yu-Hsiu Liu, Jeng-Fu Kuo
  Frontiers in Endocrinology.2019;[Epub]     CrossRef
• Impact of diabetes mellitus on the contractile properties of the left and right atrial myofilaments†
  Constanze Bening, Khaled Alhussini, Elena-Aura Mazalu, Jonathan Yaqub, Khaled Hamouda, Dejan Radakovic, Christoph Schimmer, Grzegorz Hirnle, Rainer Leyh
  European Journal of Cardio-Thoracic Surgery.2018; 54(5): 826.     CrossRef
• LAZ3 protects cardiac remodeling in diabetic cardiomyopathy via regulating miR-21/PPARa signaling
  Lu Gao, Yuan Liu, Sen Guo, Lili Xiao, Leiming Wu, Zheng Wang, Cui Liang, Rui Yao, Yanzhou Zhang
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2018; 1864(10): 3322.     CrossRef
• Gene expression profiles of rat MMECs with different glucose levels and fgl2 gene silencing
  Zhenzhong Zheng, Fan Zhang, Dengpeng Gao, Yujing Wu, Hao Wu
  Diabetes/Metabolism Research and Reviews.2018;[Epub]     CrossRef
• Empagliflozin Ammeliorates High Glucose Induced-Cardiac Dysfuntion in Human iPSC-Derived Cardiomyocytes
  Kwong-Man Ng, Yee-Man Lau, Vidhu Dhandhania, Zhu-Jun Cai, Yee-Ki Lee, Wing-Hon Lai, Hung-Fat Tse, Chung-Wah Siu
  Scientific Reports.2018;[Epub]     CrossRef
• Apelin‑13 ameliorates metabolic and cardiovascular disorders in a rat model of type 2 diabetes with a high‑fat diet
  Meng Li, Huijuan Fang, Jian Hu
  Molecular Medicine Reports.2018;[Epub]     CrossRef
• Adriamycin-induced cardiomyopathy can serve as a model for diabetic cardiomyopathy – a hypothesis
  Kaviyarasi Renu, V.G. Abilash, P.B. Tirupathi Pichiah, Thabassum Akthar Syeda, Sankarganesh Arunachalam
  Asian Pacific Journal of Tropical Biomedicine.2017; 7(11): 1041.     CrossRef